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Heat stress-induced platelet dysfunction is associated with loss of fibrinogen and is improved by fibrinogen supplementation.
Hung-Yen Ke
Jye-Hann Chen
Shih-Yao Kao
Cheng-Ming Tsao
Chia-Wen Kuo
Chin-Chen Wu
Chih-Chin Shih
Published in:
Thrombosis research (2024)
An early use of fibrinogen replacement may serve as a therapeutic intervention to alleviate platelet hyporeactivity and prevent the complications in patients with heatstroke.
Keyphrases
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heat stress
randomized controlled trial
heat shock
high glucose
oxidative stress
diabetic rats
risk factors
endothelial cells