Aryl Hydrocarbon Receptor and Dioxin-Related Health Hazards-Lessons from Yusho.
Masutaka FurueYuji IshiiKiyomi TsukimoriGaku TsujiPublished in: International journal of molecular sciences (2021)
Poisoning by high concentrations of dioxin and its related compounds manifests variable toxic symptoms such as general malaise, chloracne, hyperpigmentation, sputum and cough, paresthesia or numbness of the extremities, hypertriglyceridemia, perinatal abnormalities, and elevated risks of cancer-related mortality. Such health hazards are observed in patients with Yusho (oil disease in Japanese) who had consumed rice bran oil highly contaminated with 2,3,4,7,8-pentachlorodibenzofuran, polychlorinated biphenyls, and polychlorinated quaterphenyls in 1968. The blood concentrations of these congeners in patients with Yusho remain extremely elevated 50 years after onset. Dioxins exert their toxicity via aryl hydrocarbon receptor (AHR) through the generation of reactive oxygen species (ROS). In this review article, we discuss the pathogenic implication of AHR in dioxin-induced health hazards. We also mention the potential therapeutic use of herbal drugs targeting AHR and ROS in patients with Yusho.
Keyphrases
- reactive oxygen species
- public health
- healthcare
- mental health
- cell death
- dna damage
- health information
- human health
- health promotion
- drug induced
- heavy metals
- mycobacterium tuberculosis
- cystic fibrosis
- oxidative stress
- pulmonary tuberculosis
- fatty acid
- cardiovascular disease
- risk factors
- polycyclic aromatic hydrocarbons
- drinking water
- endothelial cells