Validation of serotonin transporter mRNA as a quantitative biomarker of heavy drinking and its comparison to ethyl glucuronide/ethyl sulfate: A randomized, double-blind, crossover trial.

Jessica CornellAndrew ConchasXin-Qun WangJeffrey C FinkHegang ChenMaureen A KaneNageswara PilliNassima Ait-DaoudDavid A GorelickMing D LiBankole A JohnsonChamindi Seneviratne

Published in: Alcoholism, clinical and experimental research (2022)

The findings do not validate the use of SERT as a biomarker of heavy drinking. Larger and more innovative studies addressing the effects of placebo, race, gender, and response to treatment with serotonergic agents are needed to fully assess the utility of SERT as a biomarker of heavy and binge drinking.

Keyphrases

double blind
phase iii
placebo controlled
clinical trial
alcohol consumption
phase ii
open label
ionic liquid
randomized controlled trial
high resolution
mass spectrometry
binding protein
combination therapy