Low expression of miR-204 is associated with expression of CD34 and poor performance status in denovo AML.

Ahmed Samir AbdelhafizGhada M ElsayedMagdy M SaberAbdallah GameelNayera Hamdy

Published in: International journal of laboratory hematology (2020)

To the best of our knowledge; this is the first time to prove the correlation between miR-204 expression and CD34 expression. Further study of this correlation is needed to confirm the role of miR-204 in CD34-positive cells, including leukemic stem cells. This correlation may have therapeutic implications. MiR-204 can be used as a biomarker for PS in AML patients.

Keyphrases

poor prognosis
long non coding rna
cell proliferation
stem cells
long noncoding rna
acute myeloid leukemia
healthcare
binding protein
induced apoptosis
prognostic factors
cell death
mesenchymal stem cells
endoplasmic reticulum stress
signaling pathway
patient reported outcomes
pi k akt