Login / Signup

Clinical Benefit of Ripretinib Dose Escalation After Disease Progression in Advanced Gastrointestinal Stromal Tumor: An Analysis of the INVICTUS Study.

Zalcberg JohnMichael C HeinrichSuzanne GeorgeSebastian BauerPatrick SchöffskiCésar SerranoHans GelderblomRobin L JonesSteven AttiaGina D'AmatoPing ChiPeter ReichardtNeeta SomaiahJulie MeadeVienna ReichertKelvin ShiMatthew L ShermanRodrigo Ruiz-SotoMargaret von MehrenJean-Yves Blay
Published in: The oncologist (2021)
Of the 85 patients with advanced gastrointestinal stromal tumor having received at least three prior anticancer therapies randomized to ripretinib 150 mg once daily (QD) in the phase III INVICTUS study, 43 underwent ripretinib intrapatient dose escalation (IPDE) to 150 mg b.i.d. after progressive disease (PD). Median progression-free survival was 4.6 months before and 3.7 months after ripretinib IPDE. The safety profile of ripretinib 150 mg b.i.d. was acceptable. These findings indicate ripretinib IPDE to 150 mg b.i.d. may provide additional clinical benefit in patients with PD on ripretinib 150 mg QD, for whom limited treatment options exist.
Keyphrases
  • phase iii
  • open label
  • free survival
  • clinical trial
  • double blind
  • phase ii
  • placebo controlled
  • randomized controlled trial