Synovial 5-Lipoxygenase-Derived Oxylipins Define a Lympho-Myeloid-Enriched Synovium.
Jessica D Murillo-SaichRoxana CorasJulio RamírezEstefania Quesada-MasachsMarta Sala-ClimentKatharina EschelbachChristopher B MahonyRaquel CelisAaron ArmandoOswald QuehenbergerAdam P CroftArthur KavanaughEric ChangJuan D CañeteAbha SinghMónica GumaPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
The lack of correlation between ST and plasma oxylipins suggests that ST lipid profiling better characterizes active pathways in treated joints. Synovial 5-LOX-derived oxylipins were highly expressed in lympho-myeloid-enriched synovium. Combination therapy with 5-LOX inhibitors to improve refractory inflammation may be needed in patients with this histologic group.