Distinct long-term disease activity trajectories differentiate early on treatment with etanercept in both rheumatoid arthritis and spondylarthritis patients: a prospective cohort study.
Irini FlouriPanagiota GoutakoliArgyro RepaAntonios Konstantinos BertsiasNestor AvgoustidisAnastasios EskitzisSofia PitsigavdakiEleni KalogiannakiMaria TerizakiGeorge K BertsiasProdromos SidiropoulosPublished in: Rheumatology international (2023)
To characterize disease activity trajectories and compare long-term drug retention between rheumatoid (RA) and spondylarthritis (SpA) patients initiating tumor necrosis factor inhibitor (TNFi) treatment (etanercept). Prospective observational study of RA, axial (AxSpA) and peripheral SpA (PerSpA) patients initiating etanercept during 2004-2020. Kaplan-Meier plots were used for drug retention comparisons and multivariable Cox regression models for predictors of discontinuation. Long-term disease activity trajectories were identified by latent class growth models using DAS28-ESR or ASDAS-CRP as outcome for RA and AxSpA respectively. We assessed 711 patients (450 RA, 178 AxSpA and 83 PerSpA) with a median (IQR) follow-up of 12 (5-32) months. At 5 years, 22%, 30% and 21% of RA, AxSpA and PerSpA patients, respectively, remained on therapy. Etanercept discontinuation was independent of the diagnosis and was predicted by gender and obesity in both RA and SpA groups. Four disease activity (DA) trajectories were identified from 6th month of treatment in both RA and AxSpA. RA patients in remission-low DA groups (33.7%) were younger, had shorter disease duration, fewer comorbidities and lower baseline disease activity compared to moderate (40.6%) & high DA (25.7%) groups. In AxSpA 74% were in inactive-low DA and they were more often males, non-obese and had lower number of comorbidities compared to higher ASDAS-CRP trajectories. In RA and AxSpA patients, disease activity trajectories revealed heterogeneity of TNFi treatment responses and prognosis. Male gender, lower baseline disease activity and fewer comorbidities, characterize a favourable outcome in terms of disease burden accrual and TNFi survival.
Keyphrases
- disease activity
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- systemic lupus erythematosus
- juvenile idiopathic arthritis
- end stage renal disease
- newly diagnosed
- ejection fraction
- depressive symptoms
- chronic kidney disease
- stem cells
- interstitial lung disease
- mental health
- type diabetes
- weight loss
- electronic health record
- adipose tissue
- risk factors
- ulcerative colitis
- bariatric surgery
- patient reported
- insulin resistance
- smoking cessation
- replacement therapy
- high intensity
- idiopathic pulmonary fibrosis