Comparison of liposomal and 2-hydroxypropyl-β-cyclodextrin-lidocaine on cell viability and inflammatory response in human keratinocytes and gingival fibroblasts.

Luiz Eduardo Nunes FerreiraBruno Vilela MunizCleiton Pita Dos SantosMaria Cristina VolpatoEneida de PaulaFrancisco Carlos Groppo

Published in: The Journal of pharmacy and pharmacology (2016)

The effect of drug carrier in the lidocaine effects was dependent on the cell type, concentration and time of exposure. MLV and HP-β-CD showed benefits in improving cell viability; however, both of them showed a tendency to increase cytokine release when compared to the plain solution.

Keyphrases

inflammatory response
endothelial cells
lipopolysaccharide induced
induced pluripotent stem cells
lps induced
pluripotent stem cells
extracellular matrix
toll like receptor
ionic liquid
emergency department
capillary electrophoresis
wound healing
adverse drug
solid state