Comparison of liposomal and 2-hydroxypropyl-β-cyclodextrin-lidocaine on cell viability and inflammatory response in human keratinocytes and gingival fibroblasts.
Luiz Eduardo Nunes FerreiraBruno Vilela MunizCleiton Pita Dos SantosMaria Cristina VolpatoEneida de PaulaFrancisco Carlos GroppoPublished in: The Journal of pharmacy and pharmacology (2016)
The effect of drug carrier in the lidocaine effects was dependent on the cell type, concentration and time of exposure. MLV and HP-β-CD showed benefits in improving cell viability; however, both of them showed a tendency to increase cytokine release when compared to the plain solution.