Chronic Hepatitis C Virus Infection Modulates the Transcriptional Profiles of CD4+ T Cells.

Michal HolubAlžběta StráníkováOndřej BeranSimona ArientováOldřich BartošKateřina KondelkováStanislav PlíšekPavel Chalupa

Published in: The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale (2021)

Chronic HCV infection is associated with downregulation of TFs Gata3 and Rorγt polarizing CD4+ T cells into Th2 and Th17 phenotypes together with upregulation of Foxp3 responsible for induction of regulatory T cells suppressing immune response.

Keyphrases

regulatory t cells
dendritic cells
hepatitis c virus infection
immune response
signaling pathway
transcription factor
cell proliferation
hepatitis c virus
gene expression
poor prognosis
toll like receptor
oxidative stress
long non coding rna
heat shock