Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase.

P SimonenS LiN K ChuaA-M LampiV PiironenJ LommiJ SinisaloAndrew J BrownE IkonenHelena Gylling

Published in: Journal of internal medicine (2020)

These novel findings demonstrate that amiodarone blocks the cholesterol synthesis pathway by inhibiting DHCR24, causing a robust accumulation of cellular desmosterol in cells and in the sera of amiodarone-treated patients. It is conceivable that the antiarrhythmic potential and side effects of amiodarone may in part result from inhibition of the cholesterol synthesis pathway.

Keyphrases

low density lipoprotein
newly diagnosed
signaling pathway
induced apoptosis
end stage renal disease
ejection fraction
prognostic factors
cell cycle arrest
risk assessment
patient reported outcomes
cell death
atrial fibrillation
endoplasmic reticulum stress
catheter ablation