Expression of urokinase-type plasminogen activator system in non-metastatic prostate cancer.

Shoji KimuraDavid D'AndreaTakehiro IwataBeat FoersterFlorian JanischMehdi Kardoust PariziMarco MoschiniAlberto BrigantiMarko BabjukPiotr ChlostaPierre I KarakiewiczDmitry EnikeevLeonid M RapoportVeronica SeebacherShin EgawaMohammad AbufarajShahrokh F Shariat

Published in: World journal of urology (2019)

Overexpression of uPA, uPAR, and PAI-1 in PCa tissue were each associated with worse BCR. Additionally, overexpression of all three markers is informative even in patients with favorable pathologic characteristics potentially helping clinical decision-making regarding adjuvant therapy and/or intensified follow-up.

Keyphrases

prostate cancer
decision making
cell proliferation
poor prognosis
transcription factor
radical prostatectomy
squamous cell carcinoma
acute lymphoblastic leukemia
small cell lung cancer
neoadjuvant chemotherapy
tyrosine kinase
locally advanced
binding protein
lymph node