Clinical and Real-World Effectiveness of Mogamulizumab: A Narrative Review.
Montserrat Fernández-GuarinoPablo OrtizFernando GallardoMar Llamas VelascoPublished in: International journal of molecular sciences (2024)
Mogamulizumab (MOG) is an antibody targeting the CCR4 receptor, authorized for relapsed or refractory peripheral T-cell (PTCL) and cutaneous T-cell lymphomas (CTCL). Its adoption in guidelines and endorsement by FDA and EMA established it as a systemic treatment, especially for advanced disease stages due to its comparatively lower toxicity. Clinical trials and real-world evidence have underscored its efficacy in advanced CTCLs, including mycosis fungoides and Sézary syndrome; PTCLs; and adult T-cell leukemia/lymphoma (ATLL), showcasing positive outcomes. Notably, the drug has demonstrated significant response rates, disease stability, and extended periods of progression-free survival, suggesting its applicability in cases with multiple treatment lines. Its safety profile is generally manageable, with adverse events (AEs) primarily related to the skin, infusion-related reactions, drug eruptions, autoimmune diseases, and skin disorders. The latter seem to appear as CCR4 can promote the skin-specific homing of lymphocytes, and MOG is directed against this receptor. While combination with immunostimulatory agents like interferon alpha and interleukin 12 has shown promising results, caution is urged when combining with PD1 inhibitors due to the heightened risk of immune-mediated AEs. The introduction of MOG as a systemic treatment implies a significant advancement in managing these diseases, supported by its favorable safety profile and complementary mechanisms.
Keyphrases
- clinical trial
- dendritic cells
- randomized controlled trial
- diffuse large b cell lymphoma
- low dose
- acute myeloid leukemia
- systematic review
- wound healing
- emergency department
- soft tissue
- acute lymphoblastic leukemia
- bone marrow
- metabolic syndrome
- regulatory t cells
- immune response
- drug delivery
- combination therapy
- adipose tissue
- replacement therapy
- weight loss
- double blind