PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation.
Srikanth PerikeFrancisco J Gonzalez-GonzalezIssam H Abu-TahaFrederick W DamenLaurin M HanftKen S LizamaAnahita AboonabiAndrielle E CapoteYuriana Aguilar-SanchezBenjamin S LevinZhenbo HanArvind SridharJacob GrandJody L MartinJoseph G AkarChad M WarrenR John SolaroSang-Ging OngDawood DarbarKerry S McDonaldCraig J GoergenBeata M WolskaDobromir DobrevXander H T WehrensMark D McCauleyPublished in: Circulation research (2023)
Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.
Keyphrases
- atrial fibrillation
- catheter ablation
- left atrial
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- heart failure
- percutaneous coronary intervention
- cell proliferation
- type diabetes
- cancer therapy
- high fat diet induced
- amino acid
- metabolic syndrome
- small molecule
- protein protein
- acute coronary syndrome
- adipose tissue
- venous thromboembolism
- skeletal muscle
- mitral valve
- left ventricular