Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma.
Shailender BhatiaNatalie V LonginoNatalie J MillerRima KulikauskasJayasri G IyerDafina IbraniAstrid BlomDavid R ByrdUpendra ParvathaneniChristopher G TwittyJean S CampbellMai H LeSharron GargoskyRobert H PierceRichard HellerAdil I DaudPaul T NghiemPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
I.t.-tavo-EP was safe and feasible without systemic toxicity. Sustained local expression of IL12 protein and local inflammation led to systemic immune responses and clinically meaningful benefit in some patients. Gene electrotransfer, specifically i.t.-tavo-EP, warrants further investigation for immunotherapy of cancer.
Keyphrases
- immune response
- end stage renal disease
- oxidative stress
- newly diagnosed
- ejection fraction
- escherichia coli
- poor prognosis
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- binding protein
- crispr cas
- toll like receptor
- patient reported outcomes
- squamous cell carcinoma
- squamous cell
- dendritic cells
- small molecule
- long non coding rna
- lymph node metastasis