PTN from Leydig cells activates SDC2 and modulates human spermatogonial stem cell proliferation and survival via GFRA1.

Xueheng ZhaoLvjun LiuZenghui HuangFang ZhuHuan ZhangDai Zhou

Published in: Biological research (2024)

Our results uncover a novel mechanism of human SSC regulation by the testicular microenvironment and suggest a potential therapeutic target for male infertility.

Keyphrases

endothelial cells
cell proliferation
induced pluripotent stem cells
induced apoptosis
stem cells
pluripotent stem cells
cell cycle
signaling pathway
risk assessment
pi k akt
oxidative stress
adipose tissue
metabolic syndrome
cell death
free survival