A Quantitative Centrosomal Amplification Score Predicts Local Recurrence of Ductal Carcinoma In Situ.
Karuna MittalMichael S TossGuanhao WeiJaspreet KaurDa Hoon ChoiBrian D MeltonRemus M OsanIslam M MiligyAndrew R GreenEmiel A M JanssenHåvard SøilandKeerthi GogineniUpender MannePadmashree RidaEmad A RakhaRitu AnejaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
CAS predicted 10-year LR risk for patients who underwent surgical management alone and identified patients who may be at low risk of recurrence, and for whom adjuvant RT may not be required. CAS demonstrated the highest concordance among the known prognostic models such as VNPI and clinicopathologic variables such as grade, age, and comedo necrosis.