Systematic comparative analysis of single-nucleotide variant detection methods from single-cell RNA sequencing data.

Fenglin LiuYuanyuan ZhangLei ZhangZiyi LiQiao FangRanran GaoYuanyuan Zhang

Published in: Genome biology (2019)

We recommend SAMtools, Strelka2, FreeBayes, or CTAT, depending on the specific conditions of usage. Our study provides the first benchmarking to evaluate the performances of different SNV detection tools for scRNA-seq data.

Keyphrases

single cell
rna seq
electronic health record
loop mediated isothermal amplification
big data
high throughput
label free
real time pcr
genome wide
gene expression
machine learning
data analysis
artificial intelligence
sensitive detection