Inhibition of HDAC3 Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice In Vivo and In Vitro.
Bo ZhaoQuan YuanJia-Bao HouZhong-Yuan XiaLi-Ying ZhanMei LiMeng JiangWen-Wei GaoLian LiuPublished in: Journal of diabetes research (2019)
These results suggested that the HDAC3 was involved in the pathological process of the complex disease of diabetic stroke. Suppression of HDAC3 exerted protective effects against cerebral I/R injury in diabetic state in vivo and in vitro via the modulation of oxidative stress, apoptosis, and autophagy, which might be mediated by the upregulation of Bmal1.
Keyphrases
- oxidative stress
- histone deacetylase
- endoplasmic reticulum stress
- subarachnoid hemorrhage
- type diabetes
- cell death
- cerebral ischemia
- wound healing
- signaling pathway
- induced apoptosis
- atrial fibrillation
- diabetic rats
- dna damage
- ischemia reperfusion injury
- cell cycle arrest
- poor prognosis
- cell proliferation
- brain injury
- blood brain barrier
- heat stress