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Lipid peroxidation in diamond supported bilayers.

A R Ortiz MorenoR LiK WuRomana Schirhagl
Published in: Nanoscale (2023)
Lipid peroxidation is a process that occurs in cells when they are exposed to oxidative stress. During the process reactive oxygen species attack lipids within the lipid bilayers of cells. Since the products of lipid peroxidation are toxic and carcinogenic, it is important to understand where and how it occurs with nanoscale resolution. The radical intermediates of this process are particularly interesting since they are causing chain reactions damaging large parts of the lipid membranes in cells. However, they are also difficult to measure for the state of the art because they are short lived and reactive. Here, we study the lipid peroxidation of three artificial lipid bilayers on a diamonds substrate that can be used to study lipid peroxidation. In particular, we present a diamond quantum sensing method called T 1 -relaxometry that allows for in situ measurements and imaging of radical intermediates of lipid peroxidation in these membranes.
Keyphrases
  • fatty acid
  • induced apoptosis
  • oxidative stress
  • molecular dynamics simulations
  • endoplasmic reticulum stress
  • cell cycle arrest
  • dna damage
  • cell proliferation
  • mass spectrometry
  • pi k akt
  • diabetic rats