Prostatic adenocarcinoma CNS parenchymal and dural metastases: alterations in ERG, CHD1 and MAP3K7 expression.
David Ryan OrmondB K Kleinschmidt-DeMastersDaniel CavalcanteElizabeth E SmithScott D CramerM Scott LuciaPublished in: Journal of neuro-oncology (2019)
Metastatic prostatic carcinoma to CNS demonstrates expression patterns consistent with particularly aggressive behavior. Lower ERG expression in dural and intraparenchymal metastases suggests a possibility that ERG-negative tumors with loss of MAP3K7 may become resistant to standard therapies and diffusely metastasize.