Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits.
Ahmad KaramiSajad FakhriLeila KooshkiHaroon KhanPublished in: Molecules (Basel, Switzerland) (2022)
Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. Polydatin possesses potential biological activities predominantly through the modulation of pivotal signaling pathways involved in inflammation, oxidative stress, and apoptosis. Various imperative biological activities have been suggested for polydatin towards promising therapeutic effects, including anticancer, cardioprotective, anti-diabetic, gastroprotective, hepatoprotective, neuroprotective, anti-microbial, as well as health-promoting roles on the renal system, the respiratory system, rheumatoid diseases, the skeletal system, and women's health. In the present study, the therapeutic targets, biological activities, pharmacological mechanisms, and health benefits of polydatin are reviewed to provide new insights to researchers. The need to develop further clinical trials and novel delivery systems of polydatin is also considered to reveal new insights to researchers.
Keyphrases
- oxidative stress
- public health
- healthcare
- mental health
- clinical trial
- health information
- human health
- randomized controlled trial
- dna damage
- microbial community
- induced apoptosis
- health promotion
- adipose tissue
- systemic lupus erythematosus
- rheumatoid arthritis
- dna methylation
- risk assessment
- endoplasmic reticulum stress
- ischemia reperfusion injury
- epithelial mesenchymal transition
- cerebral ischemia
- cell cycle arrest
- open label
- single cell
- diabetic rats
- heat stress