Bone-marrow mononuclear cells and acellular human amniotic membrane improve global cardiac function without inhibition of the NLRP3 Inflammasome in a rat model of heart failure.
Aline L TakejimaPaulo André Bispo Machado JÚniorGustavo Gavazzoni BlumeRossana Baggio SimeoniJulio César FranciscoMurilo Sgarbossa TonialLuis Felipe B MarquezeAnna Flávia Ribeiro Dos Santos MiggiolaroMarcia OlandoskiEltyeb AbdelwaidKatherine Athayde Teixeira de CarvalhoRicardo Aurino PinhoLuiz César Guarita-SouzaPublished in: Anais da Academia Brasileira de Ciencias (2024)
Recent studies have suggested that therapies with stem cells and amniotic membrane can modulate the inflammation following an ischemic injury in the heart. This study evaluated the effects of bone-marrow mononuclear cells (BMMC) and acellular human amniotic membrane (AHAM) on cardiac function and NLRP3 complex in a rat model of heart failure.On the 30th day,the echocardiographic showed improvements on ejection fraction and decreased pathological ventricular remodeling on BMMC and AHAM groups.Oxidative stress analysis was similar between the three groups,and the NLRP3 inflammasome activity were not decreased with the therapeutic use of both BMMC and AHAM,in comparison to the control group.
Keyphrases
- nlrp inflammasome
- heart failure
- bone marrow
- induced apoptosis
- ejection fraction
- oxidative stress
- stem cells
- left ventricular
- endothelial cells
- mesenchymal stem cells
- umbilical cord
- cell cycle arrest
- aortic stenosis
- induced pluripotent stem cells
- atrial fibrillation
- peripheral blood
- endoplasmic reticulum stress
- signaling pathway
- pluripotent stem cells
- ischemia reperfusion injury
- dna damage
- left atrial
- pulmonary hypertension
- acute heart failure
- diabetic rats
- heat stress
- cell therapy
- aortic valve