Long-course chemoradiation plus concurrent/sequential PD-1 blockade as neoadjuvant treatment for MMR-status-unscreened locally advanced rectal cancer: protocol of a multicentre, phase 2, randomised controlled trial (the POLAR-STAR trial).

Kai PangYun YangDan TianNa ZengShun CaoShen LingJiale GaoPengfei ZhaoHao WangYuan Yuan KongJie ZhangGuangyong ChenWei DengZhigang BaiLan JinGuoju WuDanyang ZhuYue WangJiaolin ZhouBin WuGuole LinYi XiaoZhidong GaoYingjiang YeXin WangAng LiJiagang HanHongwei YaoYingchi YangZhong-Tao Zhang

Published in: BMJ open (2023)

NCT05245474.

Keyphrases

locally advanced
rectal cancer
study protocol
neoadjuvant chemotherapy
phase ii study
randomized controlled trial
squamous cell carcinoma
radiation therapy
clinical trial
phase iii
open label
phase ii
ionic liquid