Immunomodulatory Activity of Carboxymethyl Pachymaran on Immunosuppressed Mice Induced by Cyclophosphamide.
Feng LiuLijia ZhangXi FengSalam Adnan IbrahimWen HuangYing LiuPublished in: Molecules (Basel, Switzerland) (2021)
The effects of immunomodulatory activity of two types of carboxymethyl pachymaran (CMP-1 and CMP-2) on cyclophosphamide (CTX)-induced mice were investigated. Both CMP-1 and CMP-2 were found to restore the splenomegaly and alleviate the spleen lesions and the mRNA expressions of TLR4, MyD88, p65 and NF-κB in spleen were also increased. CMP-1 and CMP-2 could enhance the immunity by increasing the levels of TNF-α, IL-2, IL-6, IFN-γ, Ig-A and Ig-G in serum. In addition, CMP-1 could increase the relative abundance of Bacteroidetes and reduce the relative richness of Firmicutes at the phylum level. CMP-1 and CMP-2 could reduce the relative abundance Erysipelatoclostridum at the genus level. CMP-1 and CMP-2 might enhance the immune function of immunosuppression mice by regulating the gene expression in the TLR4/NF-κB signaling pathway and changing the composition and abundance of the intestinal microbiota. The results suggested that CMP-1 and CMP-2 would be as potential immunomodulatory agents in functional foods.
Keyphrases
- signaling pathway
- gene expression
- immune response
- toll like receptor
- low dose
- pi k akt
- type diabetes
- high dose
- metabolic syndrome
- epithelial mesenchymal transition
- adipose tissue
- high fat diet induced
- antibiotic resistance genes
- cell proliferation
- mass spectrometry
- multidrug resistant
- high glucose
- endothelial cells
- microbial community
- skeletal muscle
- high speed
- binding protein