Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth.
Serena P H MaoMinji ParkRamon M CabreraJohn R ChristinGeorge S KaragiannisMaja H OktayDietmar M W ZaissScott I AbramsWenjun GuoJohn S CondeelisParaic A KennyJeffrey E SegallPublished in: Breast cancer research : BCR (2018)
Our study has revealed a previously unknown role of AREG in myoepithelial cell development and PyMT expression. AREG expression is essential for proper myoepithelial coverage of mammary ducts. Both AREG and myoepithelial cells can suppress PyMT expression. We find that lower AREG expression is associated with invasive papillary breast cancer in both the MMTV-PyMT model and human breast cancer.