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What is the relevance of FoxP3 in the tumor microenvironment and cancer outcomes?

Abdo MeyiahEyad Elkord
Published in: Expert review of clinical immunology (2024)
Different studies showed that FoxP3 expression can be associated with bad prognoses in cancer patients. However, FoxP3 could have opposing roles by enhancing cancer progression or regression. Location and expression of FoxP3 in T cells or tumor cells can have different impacts on cancer prognoses. Different factors should be considered to establish FoxP3 as a more robust prognostic biomarker and a potential therapeutic target for enhancing anti-tumor immunity and improving clinical outcomes of cancer patients.
Keyphrases
  • regulatory t cells
  • papillary thyroid
  • poor prognosis
  • squamous cell
  • lymph node metastasis
  • dendritic cells
  • type diabetes
  • squamous cell carcinoma
  • immune response
  • binding protein
  • long non coding rna
  • young adults