Association of weight loss and weight loss maintenance following diabetes diagnosis by screening and incidence of cardiovascular disease and all-cause mortality: An observational analysis of the ADDITION-Europe trial.
Jean StrelitzStephen J SharpKamlesh Khunti F MedSciRimke C VosGuy E H M RuttenKamlesh KhuntiDaniel R WitteAnnelli SandbaekNicholas J WarehamSimon J GriffinPublished in: Diabetes, obesity & metabolism (2020)
Both weight loss and weight gain after screen-detected diabetes diagnosis were associated with higher mortality, but not CVD events, particularly among participants without obesity. The clinical implications of weight loss following a diagnosis of diabetes probably depend on its magnitude and timing, and may differ by body mass index status. Personalization of weight loss advice and support may be warranted.
Keyphrases
- weight loss
- weight gain
- glycemic control
- cardiovascular disease
- bariatric surgery
- roux en y gastric bypass
- body mass index
- type diabetes
- gastric bypass
- birth weight
- cardiovascular events
- risk factors
- clinical trial
- obese patients
- physical activity
- high throughput
- coronary artery disease
- randomized controlled trial
- phase iii
- insulin resistance
- cardiovascular risk factors
- single cell