Hepatocyte expression and prognostic importance of senescence marker p21 in liver histopathology samples from dogs with chronic hepatitis.
Andre J KortumEmilie A CloupTim L WilliamsFernendo Constantino-CasasPenny J WatsonPublished in: Journal of veterinary internal medicine (2018)
Marked p21 immunopositivity in dogs with CH might be indicative of widespread hepatocellular senescence. A significant association with survival time also suggests a potential value for p21 quantification in determining prognosis.