Hepatocyte expression and prognostic importance of senescence marker p21 in liver histopathology samples from dogs with chronic hepatitis.

Andre J KortumEmilie A CloupTim L WilliamsFernendo Constantino-CasasPenny J Watson

Published in: Journal of veterinary internal medicine (2018)

Marked p21 immunopositivity in dogs with CH might be indicative of widespread hepatocellular senescence. A significant association with survival time also suggests a potential value for p21 quantification in determining prognosis.

Keyphrases

dna damage
endothelial cells
poor prognosis
stress induced
room temperature
binding protein
liver injury
human health
free survival
risk assessment