[11C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification of brain P2X7 receptors in patients with Parkinson's disease and healthy volunteers.
Donatienne Van WeehaegheMichel KooleMark E SchmidtStephanie DemanAndreas H JacobsErika SoucheKim SerdonsStefan SunaertGuy BormansWim VandenbergheKoen Van LaerePublished in: European journal of nuclear medicine and molecular imaging (2019)
[11C]JNJ717 is safe and suitable for quantifying P2X7R expression in human brain. In this pilot study, no significant differences in P2X7R binding were found between HV and PD patients. The results also suggest that genotype effects need to be incorporated in future P2X7R PET analyses.
Keyphrases
- end stage renal disease
- resting state
- endothelial cells
- white matter
- cerebral ischemia
- chronic kidney disease
- ejection fraction
- newly diagnosed
- poor prognosis
- binding protein
- traumatic brain injury
- computed tomography
- pet imaging
- functional connectivity
- lipopolysaccharide induced
- positron emission tomography
- induced pluripotent stem cells
- patient reported
- long non coding rna