Lymphocyte-specific kinase expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature.

Emily M HinchcliffCherie PaquetteJason RoszikSarah KeltingMark H StolerSamuel C MokTsz-Lun YeungQian ZhangMelinda YatesWeiyi PengPatrick HwuAmir Jazaeri

Published in: Cancer immunology, immunotherapy : CII (2019)

LCK is a better prognostic factor than CYT in ovarian cancer. In HGSOC, LCK high samples were characterized by higher expression of immunoglobulin and B-cell related genes suggesting that a cooperative interaction between tumor infiltrating T and B cells may correlate with better survival in this disease.

Keyphrases

prognostic factors
poor prognosis
binding protein
transcription factor
long non coding rna
protein kinase
oxidative stress