Multi-tissue transcriptome-wide association studies identified 235 genes for intrinsic subtypes of breast cancer.

James L LiJulian C McClellanHaoyu ZhangGuimin GaoDezheng Huo

Published in: Journal of the National Cancer Institute (2024)

Our comprehensive, multi-tissue TWAS corroborated previous GWAS loci for overall BC risk and intrinsic subtypes, while underscoring how common variation that impacts expression and splicing of genes in multiple tissue types can be used to further elucidate the etiology of BC.

Keyphrases

genome wide
poor prognosis
gene expression
dna methylation
rna seq
young adults
genome wide association study
binding protein
case control