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Selective Gram-Scale C-H Carbenoid Functionalization of N-Sulfonylarylamides with a Rhodium Catalyst.

Yi DongBo MeiXue-Peng ZhangHeng Xu
Published in: The Journal of organic chemistry (2021)
This work describes an effective Cp*RhIII-catalyzed C-H carbenoid functionalization of N-sulfonylarylamides. Compared to the previous late-stage C-H modification methods of N-sulfonylarylamide analogues, this method efficiently achieves the gram-scale transformation with 2.5 mol % Rh-catalyst loading at 0 °C or with a 0.1 mol % Rh-catalyst loading at room temperature. The reaction medium has a great influence on the reaction rate. Methanol is optimal, and adding a nonpolar solvent (such as toluene or 1,2-dichloroethane) causes the rate to decrease. Experiments and density functional theory calculations were performed to rationalize the mechanism of rate control by a polar medium.
Keyphrases
  • room temperature
  • density functional theory
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