Heng Xu

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 20

Top Topics

Idiopathic Pulmonary Fibrosis

Molecular Docking

Structure Activity Relationship

Top Venues

Journal of medicinal chemistry

The Journal of organic chemistry

Organic letters

Chemical science

This page only lists publications with an associated author ORCID identifier.

Publications

Yan Zhang, Jialing Deng, Hua Tian, Haixiang Qi, Tianning Xiong, Songwen Lin, Yi Dong, Lijun Luo, Deyu Wu, Kehui Zhang, Ming Ji, Tingting Du, Li Sheng, Xiaoguang Chen, Heng Xu
Design, Synthesis, and Bioevaluation of Novel Reversibly Photoswitchable PI3K Inhibitors Based on Phenylazopyridine Derivatives toward Light-Controlled Cancer Treatment. Journal of medicinal chemistry 67 (5) (2024)
Shouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng Xu
Design, synthesis and biological evaluation of a novel PSMA-PI3K small molecule drug conjugate. RSC medicinal chemistry (2024)
Yan Zhang, Jialing Deng, Hua Tian, Haixiang Qi, Tianning Xiong, Songwen Lin, Yi Dong, Lijun Luo, Deyu Wu, Kehui Zhang, Ming Ji, Tingting Du, Li Sheng, Xiaoguang Chen, Heng Xu
Design, Synthesis, and Bioevaluation of Novel Reversibly Photoswitchable PI3K Inhibitors Based on Phenylazopyridine Derivatives toward Light-Controlled Cancer Treatment. Journal of medicinal chemistry (2024)
Yan Zhang, Jialing Deng, Hua Tian, Haixiang Qi, Tianning Xiong, Songwen Lin, Yi Dong, Lijun Luo, Deyu Wu, Kehui Zhang, Ming Ji, Tingting Du, Li Sheng, Xiaoguang Chen, Heng Xu
Design, Synthesis, and Bioevaluation of Novel Reversibly Photoswitchable PI3K Inhibitors Based on Phenylazopyridine Derivatives toward Light-Controlled Cancer Treatment. Journal of medicinal chemistry 67 (5) (2024)
Hua Tian, Tingting Hou, Xin Yang, Heng Xu, Yi Dong
Cp*Ir III -Catalyzed C 8 -Selective C-H Activation Enables Room-Temperature Direct Arylation of Quinoline N -Oxides with Arylsilanes. The Journal of organic chemistry (2023)
Hua Tian, Shen You, Tianning Xiong, Ming Ji, Kehui Zhang, Lin Jiang, Tingting Du, Ying Li, Wenqian Liu, Songwen Lin, Xiaoguang Chen, Heng Xu
Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release. ACS medicinal chemistry letters 14 (8) (2023)
Songwen Lin, Tingting Du, Jingbo Zhang, Deyu Wu, Hua Tian, Kehui Zhang, Lin Jiang, Duo Lu, Li Sheng, Yan Li, Ming Ji, Xiaoguang Chen, Heng Xu
Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. Journal of medicinal chemistry (2022)
Jingbo Zhang, Huimin Jiang, Songwen Lin, Deyu Wu, Hua Tian, Lin Jiang, Yiman Cui, Jing Jin, Xiaoguang Chen, Heng Xu
Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies. Journal of medicinal chemistry 65 (11) (2022)
Deyu Wu, Zhengqiang Liu, Yiting Chang, Jiajing Chen, Haixiang Qi, Yi Dong, Heng Xu
Cp*Co III -catalyzed formal [4 + 2] cycloaddition of 2-phenyl-1 H -imidazoles to afford imidazo[1,2- c ]quinazoline derivatives. Organic & biomolecular chemistry 20 (24) (2022)
Songwen Lin, Tingting Du, Jingbo Zhang, Deyu Wu, Hua Tian, Kehui Zhang, Lin Jiang, Duo Lu, Li Sheng, Yan Li, Ming Ji, Xiaoguang Chen, Heng Xu
Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. Journal of medicinal chemistry 65 (24) (2022)
Songwen Lin, Tingting Du, Jingbo Zhang, Deyu Wu, Hua Tian, Kehui Zhang, Lin Jiang, Duo Lu, Li Sheng, Yan Li, Ming Ji, Xiaoguang Chen, Heng Xu
Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. Journal of medicinal chemistry 65 (24) (2022)
Songwen Lin, Tingting Du, Jingbo Zhang, Deyu Wu, Hua Tian, Kehui Zhang, Lin Jiang, Duo Lu, Li Sheng, Yan Li, Ming Ji, Xiaoguang Chen, Heng Xu
Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. Journal of medicinal chemistry 65 (24) (2022)
Yi Dong, Rong Fu, Jiajing Chen, Kehui Zhang, Ming Ji, Mingjin Wang, Huimin Jiang, Wei Ye, Jinping Hu, Yan Li, Jing Jin, Xiaoguang Chen, Heng Xu
Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. Journal of medicinal chemistry 64 (22) (2021)
Yi Dong, Bo Mei, Xue-Peng Zhang, Heng Xu
Selective Gram-Scale C-H Carbenoid Functionalization of N-Sulfonylarylamides with a Rhodium Catalyst. The Journal of organic chemistry 86 (17) (2021)
Kehui Zhang, Ming Ji, Songwen Lin, Shouguo Peng, Zhihui Zhang, Mingyi Zhang, Jingbo Zhang, Yan Zhang, Deyu Wu, Hua Tian, Xiaoguang Chen, Heng Xu
Design, Synthesis, and Biological Evaluation of a Novel Photocaged PI3K Inhibitor toward Precise Cancer Treatment. Journal of medicinal chemistry 64 (11) (2021)
Kehui Zhang, Fangfang Lai, Songwen Lin, Ming Ji, Jingbo Zhang, Yan Zhang, Jing Jin, Rong Fu, Deyu Wu, Hua Tian, Nina Xue, Li Sheng, Xiaowen Zou, Yan Li, Xiaoguang Chen, Heng Xu
Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases. Journal of medicinal chemistry 62 (15) (2019)
Songwen Lin, Jing Jin, Ying Liu, Hua Tian, Yan Zhang, Rong Fu, Jingbo Zhang, Mingjin Wang, Tingting Du, Ming Ji, Deyu Wu, Kehui Zhang, Li Sheng, Yan Li, Xiaoguang Chen, Heng Xu
Discovery of 4-Methylquinazoline Based PI3K Inhibitors for the Potential Treatment of Idiopathic Pulmonary Fibrosis. Journal of medicinal chemistry 62 (19) (2019)
Yi Dong, XuePeng Zhang, Jiajing Chen, Wenxing Zou, Songwen Lin, Heng Xu
Switching the site-selectivity of C-H activation in aryl sulfonamides containing strongly coordinating N-heterocycles. Chemical science 10 (38) (2019)
Yi Dong, Jiajing Chen, Yunjian Cui, Liangliang Bao, Heng Xu
Cp*RhIII-Catalyzed Sulfonamide-Directed Ortho Arene C-H Carbenoid Functionalization with Pyridotriazoles. Organic letters 22 (3) (2019)
Songwen Lin, Chunyang Wang, Ming Ji, Deyu Wu, Yuanhao Lv, Kehui Zhang, Yi Dong, Jing Jin, Jiajing Chen, Jingbo Zhang, Li Sheng, Yan Li, Xiaoguang Chen, Heng Xu
Discovery and Optimization of 2-Amino-4-methylquinazoline Derivatives as Highly Potent Phosphatidylinositol 3-Kinase Inhibitors for Cancer Treatment. Journal of medicinal chemistry 61 (14) (2018)