Defects in the Proteome and Metabolome in Human Hypertrophic Cardiomyopathy.
Michael J PrevisThomas S O'LearyMichael P MorleyBradley M PalmerMartin LeWinterJaime M YobFrancis D PaganiChristopher PetucciMin-Soo KimKenneth B MarguliesZoltan AranyDaniel P KellySharlene M DayPublished in: Circulation. Heart failure (2022)
HCM hearts display profound deficits in nucleotide availability with markedly reduced capacity for fatty acid oxidation and increases in ketone bodies and branched chain amino acids. These results have important therapeutic implications for the future design of metabolic modulators to treat HCM.