The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.

Yun ZhaoGuobin ZhengShu YangShangjing LiuYifan WuYaodong MiaoZhen LiangYunqing HuaJing ZhangJia ShiDan LiYanfei ChengYunsha ZhangYuanli ChenGuanwei FanChuanrui Ma

Published in: British journal of pharmacology (2024)

PNS reduced USP2-mediated Keap1 de-ubiquitination and promoted Keap1 degradation, thereby activating Nrf2, improving iron metabolism and reducing lipid peroxidation, thus contributing to an anti-atherosclerotic outcome. Our study revealed the mechanism(s) underlying inhibition of ferroptosis and atherosclerosis by PNS.

Keyphrases

oxidative stress
cell death
cardiovascular disease
protein protein
signaling pathway
type diabetes
small molecule
fatty acid
cell wall