Pathways of IFN-alpha Activation in Patients with Cervical Intraepithelial Neoplasia (CIN).

Nelson Ranieri Tirone Carolina Guissoni Campos Kézia Jesus Aguiar Ferreira Léticia Montes Stark Jéssica Ferreira Vieira Eddie Fernando Candido Murta Márcia Antoniazi Michelin

Published in: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (2021)

Patients with high-grade lesions have increased systemic expression of IFN-α and its activation pathways in helper and cytotoxic T lymphocytes, as well as in monocytes due to an exacerbation of the immune response in these patients. This phenomenon is not accompanied by resolution of the lesion due to a defect in the IFN-α activation pathway that revealed by low local IFNAR1 expression and high local expression of SOCS1 and SOCS3.

Keyphrases

high grade
immune response
dendritic cells
poor prognosis
low grade
binding protein
end stage renal disease
newly diagnosed
chronic kidney disease
long non coding rna
regulatory t cells
prognostic factors
patient reported outcomes
intensive care unit
drug induced