Genome-wide positioning of bivalent mononucleosomes.

Subhojit SenKirsten F BlockAlice PasiniStephen B BaylinHariharan Easwaran

Published in: BMC medical genomics (2016)

We show that regional overlap of H3K4me3 and H3K27me3 chromatin tend to be upstream to the TSS, while bivalent nucleosomes with both marks are mainly promoter proximal near the TSS of CpG island-containing genes with poised/low expression. We discuss the implications of the focal enrichment of bivalent nucleosomes around the TSS on the poised chromatin state of promoters in stem cells.

Keyphrases

genome wide
dna methylation
stem cells
gene expression
copy number
transcription factor
poor prognosis
dna damage
cell therapy
long non coding rna
genome wide identification
genome wide analysis