Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors.
Konstantinos LontosYiyang WangSupriya K JoshiAndrew T FrischMcLane J WatsonAlok KumarAshley V MenkYupeng WangRachel CumberlandJason LohmuellerEsteban CarrizosaBenjamin BoyerinasGreg M DelgoffePublished in: Journal for immunotherapy of cancer (2023)
Our data further support a role for metabolic reprogramming in immunomodulatory treatments and highlight the utility of genes like PGC-1α as attractive candidates to include in cargo along with chimeric receptors or TCRs for cell therapy of solid tumors.