The mechanisms underlying alcohol-induced decreased splenic size: A network meta-analysis study.
Xiangqian LiuMuhammed BishirColin HodgkinsonDavid GoldmanSulie L ChangPublished in: Alcohol, clinical & experimental research (2023)
Our network meta-analysis revealed that excessive alcohol exposure can damage the spleen through a variety of molecular mechanisms, thereby affecting immune function and human health. We found that alcohol-mediated splenic atrophy is largely mediated by increased apoptosis signaling, migration of cells, and inhibition of splenocyte proliferation.
Keyphrases
- human health
- cell cycle arrest
- systematic review
- risk assessment
- oxidative stress
- induced apoptosis
- alcohol consumption
- endoplasmic reticulum stress
- cell death
- signaling pathway
- climate change
- diabetic rats
- high glucose
- pi k akt
- meta analyses
- randomized controlled trial
- single cell
- weight gain
- endothelial cells
- cell proliferation
- body mass index
- physical activity