M2 Muscarinic Receptor Activation Impairs Mitotic Progression and Bipolar Mitotic Spindle Formation in Human Glioblastoma Cell Lines.

Maria Di BariVanessa TombolilloFrancesco AlessandriniClaudia GuerrieroMario FioreItalia Anna AsteritiEmilia CastigliMiriam SciaccalugaGiulia Guarguaglini Francesca Degrassi Ada Maria Tata

Published in: Cells (2021)

Our data show that the M2 agonist increases aberrant mitosis in GB cell lines. These results strengthen the idea of considering M2 acetylcholine receptors a novel promising therapeutic target for the glioblastoma treatment.

Keyphrases

cell cycle
endothelial cells
electronic health record
induced pluripotent stem cells
bipolar disorder
big data
pluripotent stem cells
machine learning
cell proliferation
binding protein