Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells.

Tomoyuki IwataEri Kaneda-IkedaKeita TakahashiKatsuhiro TakedaTakayoshi NagaharaMikihito KajiyaShinya SasakiShu IshidaMinami YoshiokaShinji MatsudaKazuhisa OuharaTsuyoshi FujitaHidemi KuriharaNoriyoshi Mizuno

Published in: Journal of periodontal research (2022)

The suppressive effects of HPL cells and HGFs on BM-MSC osteogenesis were regulated by HDAC expression and histone H3 acetylation to a greater extent than that mediated by HDAC activity. Therefore, regulation of HDAC expression has prospects in clinical applications for effective periodontal regeneration, mainly, bone regeneration.

Keyphrases

histone deacetylase
bone regeneration
induced apoptosis
bone marrow
poor prognosis
endothelial cells
cell cycle arrest
stem cells
signaling pathway
binding protein
oxidative stress
long non coding rna
current status