Clinical Efficacy of Cefixime for the Treatment of Early Syphilis.
Chrysovalantis StafylisKori KeithShivani MehtaDavid TellalianPamela BurianCarl MillnerJeffrey D KlausnerPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Safe and efficacious alternative treatment options for syphilis are necessary. This randomized, 2-arm, noncomparative pilot study evaluated the efficacy of oral cefixime 400 mg in achieving a ≥4-fold rapid plasma reagin titer decrease by 3 or 6 months after treatment. The proportion of cefixime arm participants treated successfully was 87% (95% confidence interval, 69%-100%; 13/15). Clinical Trials Registration. NCT03752112.