Predictive modeling of miRNA-mediated predisposition to alcohol-related phenotypes in mouse.

Pratyaydipta RudraWen J ShiPamela RussellBrian VestalBoris TabakoffPaula HoffmanKaterina KechrisLaura Saba

Published in: BMC genomics (2018)

This work enhances association studies by identifying miRNAs that may be mediating the association between genetic markers (SNPs) and the alcohol phenotypes. It suggests a mechanism of how genetic variants are affecting traits of interest through the modification of miRNA expression.

Keyphrases

genome wide
poor prognosis
alcohol consumption
dna methylation
copy number
binding protein
long non coding rna
drug induced