Rho-Associated Protein Kinase Inhibitor and Hypoxia Synergistically Enhance the Self-Renewal, Survival Rate, and Proliferation of Human Stem Cells.

Sarah F AlsobaieTamador AlsobaieSakis Mantalaris

Published in: Stem cells and cloning : advances and applications (2022)

We showed the beneficial effect of the interaction between hypoxia and ROCK inhibition in regulating cell proliferation, pluripotency, and single-cell survival of pluripotent cells.

Keyphrases

endothelial cells
protein kinase
stem cells
cell proliferation
induced apoptosis
cell cycle arrest
signaling pathway
pi k akt
cell cycle
induced pluripotent stem cells
endoplasmic reticulum stress
pluripotent stem cells
oxidative stress
smooth muscle
free survival
embryonic stem cells
mesenchymal stem cells