PRKCSH Alternative Splicing Involves in Silica-Induced Expression of Epithelial-Mesenchymal Transition Markers and Cell Proliferation.

Rui-Xue HuangXiaodan LiuHe LiHuacheng NingPing-Kun Zhou

Published in: Dose-response : a publication of International Hormesis Society (2020)

Significant changes in alternative splicing of silicosis-associated genes occur in patients with silicosis in silica conditions. Our study provides basic founding for further investigation into the detail molecular mechanisms underlying silica-induced silicosis.

Keyphrases

epithelial mesenchymal transition
cell proliferation
high glucose
diabetic rats
pulmonary fibrosis
poor prognosis
drug induced
genome wide
oxidative stress
gene expression
signaling pathway
endothelial cells
cell cycle
binding protein
pi k akt