Investigation on the Inhibitory Effect of Wnt-5a on Colonic Mucosal Inflammation in Patients with Ulcerative Colitis.
Kazuhiko UchiyamaTomohisa TakagiKatsura MizushimaKohei AsaedaMariko KajiwaraSaori KashiwagiYuki MinagawaYuma HottaMakoto TanakaKen InoueOsamu DohiTetsuya OkayamaNaohisa YoshidaKazuhiro KatadaKazuhiro KamadaTakeshi IshikawaHiroaki YasudaHideyuki KonishiMitsuo KishimotoYuji NaitoYoshito ItohPublished in: Digestive diseases and sciences (2022)
Wnt-5a peptide suppressed colitis in mice, and decreased Wnt-5a expression was strongly associated with relapse in patients with UC. Wnt-5a may have an inhibitory effect on mucosal inflammation in UC, and Wnt-5a peptide could be a new therapeutic strategy.