Outcomes of Periodontal therapy in Rheumatoid Arthritis: the OPERA feasibility randomised trial.
Paola de PabloStefan SerbanIsabel Lopez-OlivaJoanna RooneyKirsty HillKarim RazaAndrew FilerIain L C ChappleThomas DietrichPublished in: Journal of clinical periodontology (2022)
Overall, the trial was feasible and acceptable to study participants. Recruitment and satisfactory retention into a randomised controlled trial on the effect of periodontal treatment on RA patients is possible, albeit challenging. In this feasibility study of patients with RA and periodontitis, periodontal treatment resulted in significant improvements in periodontal disease outcomes and overall RA disease activity, although complete resolution of periodontal inflammation was difficult to achieve in some cases. This article is protected by copyright. All rights reserved.
Keyphrases
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- ankylosing spondylitis
- rheumatoid arthritis patients
- end stage renal disease
- chronic kidney disease
- juvenile idiopathic arthritis
- ejection fraction
- interstitial lung disease
- study protocol
- clinical trial
- newly diagnosed
- single molecule
- adipose tissue
- insulin resistance