Lauric acid attenuates hepato-metabolic complications and molecular alterations in high-fat diet-induced nonalcoholic fatty liver disease in rats.
Ahmed A SedikRania ElgoharyEman KhalifaWagdy K B KhalilHeba I ShafeyMohamed B ShalabyMona S O GouidaYasmin M TagPublished in: Toxicology mechanisms and methods (2024)
Nonalcoholic fatty liver disease (NAFLD) has emerged as a major chronic liver illness characterized by increase of lipid content in the liver. This study investigated the role of lauric acid to treat NAFLD in male adult Sprague Dawley rats. In this study, to induce NAFLD in the rats, a high-fat diet (HFD) was administered for eight consecutive weeks. Lauric acid groups received lauric acid (250 and 500 mg/kg; orally), concurrently with HFD for eight consecutive weeks. Lauric acid could ameliorate the serum levels of TG, TC, ALT, AST, blood glucose, and insulin. Moreover, lauric acid significantly elevated the levels of SOD, GSH, catalase, and IL-10. Additionally, it lowered the hepatic levels of MDA, ROS, MPO, 4-HNE, interleukin (IL)-1β, and tumor necrosis factor (TNF-α). Furthermore, lauric acid significantly up-regulated the hepatic expression of IRS1, AMPK, PI3K, and SIRT1 genes. In parallel, lauric acid could improve the histopathological picture of the liver and reduce the liver apoptosis via decreasing the expression of annexin V (Anx V). Finally, our data proposed that lauric acid could be an effective candidate for the NAFLD treatment.
Keyphrases
- high fat diet
- blood glucose
- insulin resistance
- type diabetes
- oxidative stress
- adipose tissue
- poor prognosis
- cell death
- skeletal muscle
- blood pressure
- dna methylation
- transcription factor
- genome wide
- electronic health record
- endoplasmic reticulum stress
- young adults
- cell proliferation
- big data
- weight loss
- deep learning
- ischemia reperfusion injury