The role of iron repletion in adult iron deficiency anemia and other diseases.
Benjamin K ElstrottLubna KhanSven OlsonVikram RaghunathanThomas G DeLougheryJoseph J ShatzelPublished in: European journal of haematology (2019)
Iron deficiency anemia (IDA) is the most prevalent and treatable form of anemia worldwide. The clinical management of patients with IDA requires a comprehensive understanding of the many etiologies that can lead to iron deficiency including pregnancy, blood loss, renal disease, heavy menstrual bleeding, inflammatory bowel disease, bariatric surgery, or extremely rare genetic disorders. The treatment landscape for many causes of IDA is currently shifting toward more abundant use of intravenous (IV) iron due to its effectiveness and improved formulations that decrease the likelihood of adverse effects. IV iron has found applications beyond treatment of IDA, and there is accruing data about its efficacy in patients with heart failure, restless leg syndrome, fatigue, and prevention of acute mountain sickness. This review provides a framework to diagnose, manage, and treat patients presenting with IDA and discusses other conditions that benefit from iron supplementation.
Keyphrases
- iron deficiency
- bariatric surgery
- randomized controlled trial
- systematic review
- liver failure
- atrial fibrillation
- preterm birth
- low dose
- high dose
- intensive care unit
- gene expression
- pregnant women
- combination therapy
- young adults
- extracorporeal membrane oxygenation
- weight loss
- depressive symptoms
- deep learning
- big data
- acute respiratory distress syndrome
- obese patients
- data analysis