Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population.

Ming-Sheng TengSemon WuLung-An HsuI-Shiang TzengHsin-Hua ChouCheng-Wen SuYu-Lin Ko

Published in: Lipids in health and disease (2019)

Our data revealed that interaction and suppression effects mediated the pleiotropic association of the LIPC variants. The effects of the LIPC SNPs depended on sex, adiposity status, and TG levels. Thus, our findings can provide a method for identifying high-risk populations of cardiovascular diseases for clinical diagnosis.

Keyphrases

cardiovascular disease
copy number
genome wide
electronic health record
type diabetes
single cell
fatty acid
machine learning
physical activity
adipose tissue
coronary artery disease
weight gain
deep learning
weight loss